Technical Hurdles
Technical Hurdles
Cloning is quite inefficient and usually there are over 600 to 1000 nuclear transfers before one is able to grow into a stem cell. This inefficiency is thought to be due to genetic imprinting in the cloned adult cell that interferes with the correct gene expression in the embryo. Even those animals that are successfully cloned are not as healthy as the original animal. For example, Dolly had arthritis and sign of premature aging. See methylation and epigenetic.
PublicationsCloning and Stem Cells, published by Mary Ann Liebert, Inc., publishes peer-reviewed research papers on the remarkable new opportunities in medicine, biology, and agriculture that arise from the demonstration of far greater than expected developmental plasticity in mammalian cells. Papers cover all aspects of cloning along with the culture and differentiation of stem cells from all stages of development from embryo to adult.
Cloning is quite inefficient and usually there are over 600 to 1000 nuclear transfers before one is able to grow into a stem cell. This inefficiency is thought to be due to genetic imprinting in the cloned adult cell that interferes with the correct gene expression in the embryo. Even those animals that are successfully cloned are not as healthy as the original animal. For example, Dolly had arthritis and sign of premature aging. See methylation and epigenetic.
PublicationsCloning and Stem Cells, published by Mary Ann Liebert, Inc., publishes peer-reviewed research papers on the remarkable new opportunities in medicine, biology, and agriculture that arise from the demonstration of far greater than expected developmental plasticity in mammalian cells. Papers cover all aspects of cloning along with the culture and differentiation of stem cells from all stages of development from embryo to adult.
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